A study on the activation of the N CH bond of Morita-Baylis-Hillman adducts of N-substituted isatin with cerium ammonium nitrate (CAN) and saturated and unsaturated alcohols have been carried out. The choice of a Morita-Baylis-Hillman adduct for this study is screened with a number of adducts. A comparative and reactivity pattern study on N CH activation of Morita- Baylis-Hillman adducts of N-substituted isatin derivatives viz. N-methyl, N-ethyl, N-methyl ...