Novel and versatile strategy for the synthesis of prostanoids in the E, F, H, and I series

JR Hwu, JA Robl, BA Gilbert

文献索引：Hwu; Robl; Gilbert Journal of the American Chemical Society, 1992 ,  vol. 114,  # 8  p. 3125 - 3126

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被引用次数: 14

摘要

Prostaglandins (PGs) exist in most mammalian tissues.'Isolation of PGs from natural biosynthetic sources cannot meet their medicinal demand. 2 Total synthesis thus remains the only means by which sufficient quantities of prostanoids can be made a~ ailable.~.~ Herein we report a novel biomimetic, cascade-type synthesis4 of various prostanoids via common 1 1 a, 9cr-epoxyimino-PGHs (ie, 25 and 27).