Prostaglandins (PGs) exist in most mammalian tissues.'Isolation of PGs from natural biosynthetic sources cannot meet their medicinal demand. 2 Total synthesis thus remains the only means by which sufficient quantities of prostanoids can be made a~ ailable.~.~ Herein we report a novel biomimetic, cascade-type synthesis4 of various prostanoids via common 1 1 a, 9cr-epoxyimino-PGHs (ie, 25 and 27).
![methyl 7-((1R,4S,5R,6R)-6-((R,E)-3-hydroxyoct-1-en-1-yl)-3-phenyl-2-oxa-3-azabicyclo[2.2.1]heptan-5-yl)heptanoate Structure](https://image.chemsrc.com/caspic/255/121003-79-0.png)