Amine− guanidine switch: A promising approach to improve DNA binding and antiproliferative activities

…, M Smietana, A Restouin, S Mollard…

文献索引：Ohara, Keiichiro; Smietana, Michael; Restouin, Audrey; Mollard, Severine; Borg, Jean-Paul; Collette, Yves; Vasseur, Jean-Jacques Journal of Medicinal Chemistry, 2007 , vol. 50, # 26 p. 6465 - 6475

全文：HTML全文

被引用次数: 38

摘要

A series of polyaromatic guanidino derivatives was synthesized and evaluated for growth inhibitory properties in several human carcinoma cell lines. The properties of these guanidino compounds were compared to those of their corresponding synthetic amino precursors. The size of the polyaromatic ring system as well as the length of the tether attached to the ring had a direct impact on the observed antiproliferative profiles, ...