Macrocyclization of Di??Boc??guanidino??alkylamines Related to Guazatine Components: Discovery and Synthesis of Innovative Macrocyclic Amidinoureas

D Castagnolo, F Raffi, G Giorgi…

文献索引：Castagnolo, Daniele; Raffi, Francesco; Giorgi, Gianluca; Botta, Maurizio European Journal of Organic Chemistry, 2009 , # 3 p. 334 - 337

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被引用次数: 14

摘要

Abstract The synthesis of new and innovative macrocyclic amidinoureas from linear di-Boc- guanidino-alkylamines related to guazatine was accomplished. The macrocyclization reaction proceeds under mild conditions affording 11-to 16-membered rings with a new and previously undescribed structure in good yields. Enantiomerically pure macrocyclic amidinoureas were also synthesised. The strict correlation between macrocyclic ...