Transaminative desilylation of (aminomethyl) trimethylsilane and transitory inactivation of plasma amine oxidase

…, B Venkataraman, ME Klein, LM Sayre

文献索引：Wang, F.; Venkataraman, B.; Klein, M. E.; Sayre, L. M. Journal of Organic Chemistry, 1992 , vol. 57, # 25 p. 6687 - 6689

全文：HTML全文

被引用次数: 9

摘要

(Aminomethy1) trimethylsilane (AMTMS) was reported by Banik and Silverman to induce a slowly recoverable, mechanism-based inactivation of the mitochondrial flavin-dependent monoamine oxidase (MAO), 2 an enzyme believed to oxidize amines via initial one-electron (le) oxidation at nitrogen. The interest in AMTMS stemmed from Mariano's earlier demonstration that photochemical le oxidation of or-heteroatom-substituted silanes ...