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A simple and efficient method for α-bromination of carbonyl compounds using N-bromosuccinimide in the presence of silica-supported sodium hydrogen sulfate as a …

B Das, K Venkateswarlu, G Mahender, I Mahender

文献索引：Das, Biswanath; Venkateswarlu, Katta; Mahender, Gurram; Mahender, Ibram Tetrahedron Letters, 2005 , vol. 46, # 17 p. 3041 - 3044

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被引用次数: 104

摘要

α-Bromination of carbonyl compounds (cyclic and acyclic ketones, amides and β-ketoesters) has been achieved efficiently by treatment with N-bromosuccinimide (NBS) and catalyzed by silica-supported sodium hydrogen sulfate (NaHSO4· SiO2). The products were formed in high yields under mild reaction conditions and in short reaction times.