Quaternary salts of 2-[(hydroxyimino) methyl] imidazole. 3. Synthesis and evaluation of (alkenyloxy)-,(alkynyloxy)-, and (aralykyloxy) methyl quaternarized 2-[( …

…, I Koplovitz, WE Sultan, HA Musallam

文献索引：Bedford; Harris III; Howd; Goff; Koolpe; Petesch; Koplovitz; Sultan; Musallam Journal of Medicinal Chemistry, 1989 ,  vol. 32,  # 2  p. 504 - 516

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被引用次数: 29

摘要

Quaternary Salts of 2-[(Hydroxyimino) methyl] imadazole. 3 representing the 2- [(hydroxyimino) methyl]-3-methyl-imidazolium ring system were synthesized. As before, all compounds were evaluated with respect to (hydroxyimino) methyl acid dissociation constant, nucleophilicity, and lipophilicity. The alkynyloxy-substituted imidazolium derivatives were also evaluated for reversible inhibition of AChE and kinetics of ...