Cleavage of methoxymethyl ethers with boron trichloride. A convenient, versatile preparation of chloromethyl ether derivatives

…, RN Harris III, JC Bottaro, CD Bedford

文献索引：Goff, Dane A.; Harris, Ralph N.; Bottaro, Jeffrey C.; Bedford, Clifford D. Journal of Organic Chemistry, 1986 ,  vol. 51,  # 24  p. 4711 - 4714

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被引用次数: 43

摘要

In conjunction with our ongoing program directed toward the synthesis of potential reactivators of organophosphorous inhibited acetylcholinesterase,'we required a series of chloromethyl ethers 1 which were to be used to quaternize various oxime derivaties. Although the classical procedure for preparing type 1 compounds (eq I)* generally