Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano [4, 3-d] pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano [4, 3-d] …

…, C Brullo, S Schenone, F Bondavalli, A Ranise…

文献索引：Bruno, Olga; Brullo, Chiara; Schenone, Silvia; Bondavalli, Francesco; Ranise, Angelo; Tognolini, Massimiliano; Impicciatore, Mariannina; Ballabeni, Vigilio; Barocelli, Elisabetta Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 1 p. 121 - 130

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被引用次数: 59

摘要

Atherothrombotic coronary artery disease, associated with deep vein thrombosis, is one of the most common causes of death worldwide. Recently, antiplatelet combination therapy using agents with different mechanisms of action, such as aspirin, dipyridamole, and thienopyridines, seems to be an attractive preventive approach. Moreover, several large, randomized clinical trials support combination therapy with aspirin plus warfarin in high- ...