Tetrahedron letters

A tandem Heck reaction leading to a 26-membered carbocycle

DC Harrowven, T Woodcock, PD Howes

文献索引：Harrowven, David C.; Woodcock, Timothy; Howes, Peter D. Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9327 - 9329

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被引用次数: 13

摘要

Sequential inter-and intramolecular Heck reactions have been used to construct a 26- membered carbocycle. This new tandem reaction uses strain effects to advantage in biasing the first step towards intermolecular coupling. In the second step, the lack of strain in the formation of a large ring promotes this course over polymerisation.