New formulation of blood substitutes: optimization of novel fluorinated microemulsions

C Cecutti, I Rico, A Lattes, A Novelli, A Graciaa…

文献索引：Cecutti, Christine; Rico, Isabelle; Lattes, Armand; Novelli, Anne; Rico, Andre; et al. European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 485 - 492

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被引用次数: 17

摘要

The synthesis of a novel microemulsion system composed of a mixed fluorinated and hydrogenated oil C 8 F 17 CH 2 CH CH C 4 H 9 with a biocompatible hydrogenated surfactant, Montanox 80 is described. Investigation of the solubility of oxygen in these microemulsions showed that they absorbed more oxygen than Fluosol-DA which is currently used as an oxygen transporter in biomedical applications. Oxygen absorption was similar to that of blood. Light scattering ...