The Journal of Organic Chemistry

Palladium-catalyzed cross-coupling of perfluoroalkenylzinc reagents with aryl iodides. A new, simple synthesis of. alpha.,. beta.,. beta.-trifluorostyrenes and the …

PL Heinze, DJ Burton

文献索引：Heinze, Pamela L.; Burton, Donald J. Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2714 - 2720

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被引用次数: 115

摘要

Perfluoroalkenylzinc reagents [CF2= CFZnX (l),(2)-CF, CF= CFZnX (2), and (E)-CFSCF= CFZnX (3); X= perfluoroalkenyl group or I (Br or I for l)] coupled with aryl iodides in the presence of Pd (PPh3) 4 (1-3 mol%) to give the corresponding arylalkenes. A series of substituted a,@,@-trifluorostyrenes were prepared in good yields. This method provides ready availability of these fluorinated styrenes, which were previously obtained with ...