Triterpenoid total synthesis. Synthesis and absolute configuration of mispyric acid

Y Imamura, H Takikawa, M Sasaki…

文献索引：Imamura, Yusuke; Takikawa, Hirosato; Sasaki, Mitsuru; Mori, Kenji Organic and Biomolecular Chemistry, 2004 , vol. 2, # 15 p. 2236 - 2244

全文：HTML全文

被引用次数: 11

摘要

The first synthesis of mispyric acid (1), an inhibitor of DNA polymerase β with a novel triterpene skeleton, was achieved by starting from isoprene (2), geraniol (6) and 1, 5- dimethoxy-1, 4-cyclohexadiene (14). The absolute configuration of the naturally occurring 1 was determined as 2S, 4S.