The first synthesis of mispyric acid (1), an inhibitor of DNA polymerase β with a novel triterpene skeleton, was achieved by starting from isoprene (2), geraniol (6) and 1, 5- dimethoxy-1, 4-cyclohexadiene (14). The absolute configuration of the naturally occurring 1 was determined as 2S, 4S.
![(1,1-dimethylethyl)[(3,7-dimethyl-2(E),6-octadienyl)oxy]dimethylsilane Structure](https://image.chemsrc.com/caspic/133/80873-81-0.png)
