Synthesis and Pharmacology of Novel Analogues of Oxytocin and Deaminooxytocin: Directed Methods for the Construction of Disulfide and Trisulfide Bridges in …
…, I Zoulíková, J Slaninová, G Barany
文献索引：Chen, Lin; Zoulikova, Ivana; Slaninova, Jirina; Barany, George Journal of Medicinal Chemistry, 1997 , vol. 40, # 6 p. 864 - 876
Using as models the neurohypophyseal nonapeptide hormone oxytocin and its analogue deaminooxytocin, several directed routes to formation of sulfur-sulfur bridges have been developed and evaluated. The linear sequences (through common octapeptide-resin intermediates) were assembled smoothly on tris (alkoxy) benzylamide (PAL) poly (ethylene glycol)-polystyrene (PEG-PS) graft supports, using stepwise Fmoc solid-phase chemistry. ...
