The Journal of organic chemistry

Efficient generation of a trisporoid library by combination of synthesis and biotransformation

D Schachtschabel, W Boland

文献索引：Schachtschabel, Doreen; Boland, Wilhelm Journal of Organic Chemistry, 2007 , vol. 72, # 4 p. 1366 - 1372

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被引用次数: 29

摘要

Trisporic acids and their biosynthetic precursors represent a family of powerful fungal pheromones and morphogenetic factors. A highly flexible synthetic protocol is described that (i) provides rapid access to nonfunctionalized early trisporoids from β-ionone,(ii) includes a regiospecific oxidative functionalization of β-ionone leading to 1-acetoxy-β-ionone giving access to functionalized trisporoids, and (iii) utilizes a biotransformation of early synthetic ...