Development of paramagnetic probes for molecular recognition studies in protein kinases

J Vazquez, SK De, LH Chen…

文献索引：Vazquez, Jesus; Tautz, Lutz; Ryan, Jennifer J.; Vuori, Kristiina; Mustelin, Tomas; Pellecchia, Maurizio Journal of Medicinal Chemistry, 2007 , vol. 50, # 9 p. 2137 - 2143

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被引用次数: 30

摘要

We report on the synthesis and evaluation of an indazole-spin-labeled compound that was designed as an effective chemical probe for second site screening against the protein kinase JNK using NMR-based techniques. We demonstrate the utility of the derived