Structure–Activity relationships of novel anti-Malarial agents. Part 4: N-(3-Benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl) acrylic acid amides

…, P Wißner, O Krämer, H Jomaa, M Schlitzer

文献索引：Wiesner, Jochen; Mitsch, Andreas; Wissner, Pia; Kraemer, Oliver; Jomaa, Hassan; Schlitzer, Martin Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 19 p. 2681 - 2683

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被引用次数: 25

摘要

In a previous report, we have described novel anti-malarial compounds based on a 2, 5- diaminobenzophenone scaffold. Here, we have invesigated acryloyl derivatives carrying a biaryl structure consisting of a terminal aryl residue and a central 2-furyl ring. Several compounds were obtained in the series of para-substituted phenylfurylacryloyl derivatives that displayed improved anti-malarial activity in comparison to earlier described ...