Medicinal Chemistry Research

Synthesis and biological evaluation of resveratrol–coumarin hybrid compounds as potential antitumor agents

W Shen, J Mao, J Sun, M Sun, C Zhang

文献索引：Shen, Wei; Mao, Jianfeng; Sun, Juan; Sun, Minjie; Zhang, Can Medicinal Chemistry Research, 2013 , vol. 22, # 4 p. 1630 - 1640

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被引用次数: 12

摘要

Abstract Eighteen resveratrol–coumarin hybrid compounds (6 or 7-styryl-3-phenylcoumarin) were designed, synthesized and thirteen compounds were evaluated for their antitumor activities against MCF-7, HCT-28, and K562 tumor cell lines. Among them, compounds 2Z, 2E, 5E, and 7E showed varying degrees of growth inhibition of the above cell lines (IC 50: 3.78–19.16 μmol/L). On the basis of the biological results, structure–activity relationships ...