Tetrahedron: Asymmetry

Highly enantioselective copper-catalyzed 1, 4-conjugate addition of diethylzinc to cyclic enones and α, β-unsaturated lactones

L Liang, M Yan, YM Li, ASC Chan

文献索引：Liang, Liang; Yan, Ming; Li, Yue-Ming; Chan, Albert S.C. Tetrahedron Asymmetry, 2004 , vol. 15, # 16 p. 2575 - 2578

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被引用次数: 34

摘要

A significant improvement in enantioselectivity has been achieved in the 1, 4-additions of diethylzinc to 2-cyclopentenone, 2-cyclohexenone and 5, 6-hydro-2H-pyran-2-one (up to 93%, 98% and 94% ee, respectively) by using a chiral diphosphite–copper catalyst under suitable reaction conditions.