Ferrocene phosphane–carbene ligands in Cu-catalyzed enantioselective 1, 4-additions of Grignard reagents to α, β-unsaturated carbonyl compounds

…, M Mečiarová, A Almássy, B Horváth, R Šebesta

文献索引：Csizmadiova, Jana; Meciarova, Maria; Almassy, Ambroz; Horvath, Branislav; Sebesta, Radovan Journal of Organometallic Chemistry, 2013 , vol. 737, p. 47 - 52

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被引用次数: 13

摘要

Chiral ferrocene phosphane–carbenes are good ligands for the copper-catalyzed 1, 4- addition of Grignard reagents to various Michael acceptors. The products were obtained in high enantiomeric purity (up to er= 95: 5) and excellent regioselectivity (rr= 99: 1). These ligands are also useful for domino conjugate addition followed by enolate trapping with imine and aldehyde.