One??Pot Tandem 1, 4–1, 2??Addition of Phosphites to α, β??Unsaturated Imines for the Synthesis of Glutamic Acid Analogues
K Moonen, E Van Meenen, A Verwée…
文献索引：Moonen, Kristof; Van Meenen, Ellen; Verwee, Annelies; Stevens, Christian V. Angewandte Chemie - International Edition, 2005 , vol. 44, # 45 p. 7407 - 7411
Amino phosphonates and their corresponding amino phosphonic acids are known as amino acid mimetics and, therefore, affect the physiological activity of the cell.[1] The synthesis of 1- alkylamino phosphonates by a reaction of a dialkyl phosphite and an imine under thermal conditions had been described in the early 1950s.[2] However, dialkyl phosphites are generally considered to be poor nucleophiles because they exist predominantly in a σ4λ5 ...
