Amino phosphonates and their corresponding amino phosphonic acids are known as amino acid mimetics and, therefore, affect the physiological activity of the cell.[1] The synthesis of 1- alkylamino phosphonates by a reaction of a dialkyl phosphite and an imine under thermal conditions had been described in the early 1950s.[2] However, dialkyl phosphites are generally considered to be poor nucleophiles because they exist predominantly in a σ4λ5 ...
