Tetrahedron

Enantioposition-selective arylation of biaryl ditriflates by palladium-catalyzed asymmetric Grignard cross-coupling

T Kamikawa, T Hayashi

文献索引：Kamikawa, Takashi; Hayashi, Tamio Tetrahedron, 1999 , vol. 55, # 11 p. 3455 - 3466

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被引用次数: 67

摘要

Asymmetric cross-coupling of achiral biaryl ditriflates with aryl Grignard reagents in the presence of 1 equiv of lithium bromide and 5 mol% of palladium complex PdCl2 [(S)- alaphos], where alaphos stands for (2-dimethylamino) propyldiphenylphosphine, gave axially chiral monophenylation products with high enantioposition-selectivity. The remaining triflate group in the monophenylation products was substituted with carboxyl and ...