Organic letters

Synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling reaction

JM Becht, C Catala, C Le Drian, A Wagner

文献索引：Becht, Jean-Michel; Catala, Cedric; Le Drian, Claude; Wagner, Alain Organic Letters, 2007 , vol. 9, # 9 p. 1781 - 1783

全文：HTML全文

被引用次数: 170

摘要

A simple and efficient route to biaryls via Pd-catalyzed decarboxylative cross-couplings of arene carboxylic acids and aryl iodides is reported. The PdCl2/AsPh3 catalytic system in the presence of Ag2CO3 in DMSO was found to be particularly efficient to perform this transformation. This reaction can be extended to the synthesis of various biaryls, including sterically hindered biaryls, with yields ranging from 58% to 90%.