Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy) ethoxy] adenine

HT Serafinowska, RJ Ashton, S Bailey…

文献索引：Serafinowska; Ashton; Bailey; Harnden; Jackson; Sutton Journal of Medicinal Chemistry, 1995 , vol. 38, # 8 p. 1372 - 1379

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被引用次数: 67

摘要

@ Abstract published in Advance ACS Abstracts, March 15, 1995. lular membranes. To facilitate the cellular penetration of these molecules, a variety of protecting groups for the anionic oxygens at the phosphorus have been examined. Recently, the bis [(pivaloyloxy) methyll esters of PMEA and PMPA were shown to have 100-fold increased cellular uptake and considerably greater antiviral activity in vitro in comparison with the parent corn ...