Tetrahedron

Diversity oriented efficient access of trisubstituted purines via sequential regioselective Mitsunobu coupling and SN Ar based C 6 functionalizations

A Manvar, A Shah

文献索引：Manvar, Atul; Shah, Anamik Tetrahedron, 2013 , vol. 69, # 2 p. 680 - 691

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被引用次数: 3

摘要

An efficient protocol for the syntheses of diverse 2, 6, 7-and 2, 6, 9-trisubstituted purines is reported starting from the guanine precursor, 2-amino-6-chloropurine nucleoside through subsequent regioselective, high yielding Mitsunobu coupling and nucleophilic substitutions at C6 with versatile primary and secondary amines. A wide range of 2, 6, 7-and 2, 6, 9- trisubstituted purines were accessible in good to excellent yields with remarkable ...