Structure based development of phenylimidazole-derived inhibitors of indoleamine 2, 3-dioxygenase

S Kumar, D Jaller, B Patel, JM LaLonde…

文献索引：Kumar, Sanjeev; Jaller, Daniel; Patel, Bhumika; LaLonde, Judith M.; DuHadaway, James B.; Malachowski, William P.; Prendergast, George C.; Muller, Alexander J. Journal of Medicinal Chemistry, 2008 , vol. 51, # 16 p. 4968 - 4977

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被引用次数: 86

摘要

Indoleamine 2, 3-dioxygenase (IDO) is emerging as an important new therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression. With the goal of developing more potent IDO inhibitors, a systematic study of 4-phenylimidazole (4-PI) derivatives was undertaken. Computational docking experiments guided design and synthesis efforts with analogues of 4-PI. In ...