前往化源商城

Synthesis of benzothiazole semicarbazones as novel anticonvulsants—The role of hydrophobic domain

N Siddiqui, A Rana, SA Khan, MA Bhat…

文献索引:Siddiqui, Nadeem; Rana, Arpana; Khan, Suroor A.; Bhat, Mashooq A.; Haque, Syed E. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4178 - 4182

全文:HTML全文

被引用次数: 117

摘要

A series of 1, 3-benzothiazol-2-yl semicarbazones (1–15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character.