Synthesis and cell-based activity of a potent and selective protein tyrosine phosphatase 1B inhibitor prodrug

IG Boutselis, X Yu, ZY Zhang…

文献索引：Boutselis, Irene G.; Yu, Xiao; Zhang, Zhong-Yin; Borch, Richard F. Journal of Medicinal Chemistry, 2007 , vol. 50, # 4 p. 856 - 864

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被引用次数: 54

摘要

Our laboratory recently reported the development of novel prodrug chemistry for the intracellular delivery of phosphotyrosine mimetics. This chemistry has now been adapted for the synthesis of a prodrug that delivers the nonhydrolyzable difluoromethylphosphonate moiety intracellularly. Activation of the prodrug generates a difluoromethylphosphonamidate anion that undergoes subsequent cyclization and hydrolysis with at 1/2= 44 min. A highly ...