Tetrahedron Letters

Synthesis of substituted 2, 4, 5, 6-tetrahydrocyclopenta [c] pyrazoles and 2, 4, 5, 6-tetrahydropyrrolo [3, 4-c] pyrazoles by intramolecular nitrilimine cycloaddition

MP Winters, CA Teleha, Z Sui

文献索引：Winters, Michael P.; Teleha, Christopher A.; Sui, Zhihua Tetrahedron Letters, 2014 , vol. 55, # 13 p. 2150 - 2153

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被引用次数: 5

摘要

Abstract Both substituted 2, 4, 5, 6-tetrahydrocyclopenta [c] pyrazoles and 2, 4, 5, 6- tetrahydropyrrolo [3, 4-c] pyrazoles have been synthesized by the 3+ 2 intramolecular dipolar cycloaddition of nitrilimines to alkynes. This cyclization has been extended to more versatile 3-bromo derivatives by the use of alkynylbromides as dipolarophiles.