Bioorganic & medicinal chemistry

Synthesis and Hybridization Properties of DNA–PNA Chimeras Carrying 5-Bromouracil and 5-Methylcytosine

E Ferrer, A Shevchenko, R Eritja

文献索引：Ferrer, Elisenda; Shevchenko, Anna; Eritja, Ramon Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 2 p. 291 - 297

全文：HTML全文

被引用次数: 26

摘要

The preparation of 5-bromouracil and 5-methylcytosine peptide nucleic acid (PNA) monomers is described. These PNA monomers were used for the preparation of several DNA–PNA chimeras and their hybridization properties are described. The substitution of cytosine by 5-methylcytosine in DNA–PNA chimeras increased duplex stability while substitution of thymine by 5-bromouracil maintained it. Moreover, binding of DNA–PNA ...