Synthesis and biological characterization of [3 H](2-amino-4, 5, 6, 7-tetrahydrobenzo [b] thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine …

…, K Varani, F Vincenzi, PA Borea, R Romagnoli

文献索引：Baraldi, Pier Giovanni; Pavani, Maria Giovanna; Leung, Edward; Moorman, Allan R.; Varani, Katia; Vincenzi, Fabrizio; Borea, Pier Andrea; Romagnoli, Romeo Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1402 - 1404

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被引用次数: 17

摘要

Among the adenosine A1 allosteric enhancers reported so far, compound (2-amino-4, 5, 6, 7- tetrahydrobenzo [b] thiophen-3-yl)-(4-chlorophenyl)-methanone 1 (named T-62) has shown biological properties similar to those of PD 81,723, the reference A1 allosteric enhancer and it has been more fully pharmacologically investigated. The preparation of the radiolabelled form of compound 1 and its characterization by saturation binding experiments are ...