Synthesis and biological characterization of [3 H](2-amino-4, 5, 6, 7-tetrahydrobenzo [b] thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine …

…, K Varani, F Vincenzi, PA Borea, R Romagnoli

Index: Baraldi, Pier Giovanni; Pavani, Maria Giovanna; Leung, Edward; Moorman, Allan R.; Varani, Katia; Vincenzi, Fabrizio; Borea, Pier Andrea; Romagnoli, Romeo Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1402 - 1404

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Citation Number: 17

Abstract

Among the adenosine A1 allosteric enhancers reported so far, compound (2-amino-4, 5, 6, 7- tetrahydrobenzo [b] thiophen-3-yl)-(4-chlorophenyl)-methanone 1 (named T-62) has shown biological properties similar to those of PD 81,723, the reference A1 allosteric enhancer and it has been more fully pharmacologically investigated. The preparation of the radiolabelled form of compound 1 and its characterization by saturation binding experiments are ...