Synthesis and anti-HIV activity of nonatyrosine N-and O 1–9-decasulfate

…, K Uchino, T Saitoh, K Higashi, H Nakashima…

文献索引：Ueki, Masaaki; Watanabe, Shigeru; Ishii, Yusuke; Okunaka, Osamu; Uchino, Keijiro; Saitoh, Takeshi; Higashi, Kyoichiro; Nakashima, Hideki; Yamamoto, Naoki; Ogawara, Hiroshi Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 2 p. 477 - 486

全文：HTML全文

被引用次数: 17

摘要

To develop a potent and effective anti-HIV compound with a definite polyanionic structure, synthesis of oligotyrosine sulfates by oligomerization with simultaneous sulfation of tyrosine was tried. One component was successfully isolated from the mixture containing many products as its sodium salt (Y-ART-4) and was identified as the salt of nonatyrosine N-and O1–9-decasulfate, NaO3S–[Tyr (SO3Na)] 9–ONa. Anti-HIV activity of Y-ART-4, determined ...