Synthesis and anti-HIV activity of nonatyrosine N-and O 1–9-decasulfate

…, K Uchino, T Saitoh, K Higashi, H Nakashima…

Index: Ueki, Masaaki; Watanabe, Shigeru; Ishii, Yusuke; Okunaka, Osamu; Uchino, Keijiro; Saitoh, Takeshi; Higashi, Kyoichiro; Nakashima, Hideki; Yamamoto, Naoki; Ogawara, Hiroshi Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 2 p. 477 - 486

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Citation Number: 17

Abstract

To develop a potent and effective anti-HIV compound with a definite polyanionic structure, synthesis of oligotyrosine sulfates by oligomerization with simultaneous sulfation of tyrosine was tried. One component was successfully isolated from the mixture containing many products as its sodium salt (Y-ART-4) and was identified as the salt of nonatyrosine N-and O1–9-decasulfate, NaO3S–[Tyr (SO3Na)] 9–ONa. Anti-HIV activity of Y-ART-4, determined ...