Chemistry Letters

An Extremely High Insulin-Mimetic Activity of Bis (1, 4-dihydro-2-methyl-1-phenyl-4-thioxo-3-pyridinolato) zinc (II) Complex.

…, T Tsukahara, R Saito, KK Ghosh, Y Yoshikawa…

文献索引：Katoh, Akira; Tsukahara, Takeshi; Saito, Ryota; Ghosh, Kallol K.; Yoshikawa, Yutaka; Kojima, Yoshitane; Tamura, Asuka; Sakurai, Hiromu Chemistry Letters, 2002 , # 1 p. 114 - 115

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被引用次数: 22

摘要

Vanadyl and zinc (II) complexes with VO (O 2 S 2) and Zn (O 2 S 2) coordination mode, respectively, were synthesized. Among them, bis (1, 4-dihydro-2-methyl-1-phenyl-4-thioxo-3- pyridinolato) zinc (II) complex exhibited an extremely high insulin-mimetic activity (IC 50= 0.04 mM when IC 50 value of a positive control, VOSO 4 was estimated to be 1.0 mM) compared to vanadyl and zinc (II) complexes reported previously.