A new and improved process for celiprolol hydrochloride

…, MK Gurjar, NK Tripathy, MS Chorghade

文献索引：Joshi, Ramesh A.; Gurjar, Mukund K.; Tripathy, Narendra K.; Chorghade, Mukund S. Organic Process Research and Development, 2001 , vol. 5, # 2 p. 176 - 178

全文：HTML全文

被引用次数: 14

摘要

The key intermediate in the synthetic sequence was 2-acetyl-4-nitrophenol (10). The literature offers two methods for its preparation: (a) the Fries migration 6 of 4-nitrophenyl acetate (9) and (b) nitration of o-hydroxy acetophenone. 7 The Fries migration of 4-nitrophenyl acetate (9) using 2.2 equiv of anhydrous AlCl 3 in dry nitrobenzene gave a 25% yield of 10 after steam distillation to remove nitrobenzene. Attempts to carry out the migration by heating a concentrated ...