Isolation and structural elucidation of degradation products of alprazolam: photostability studies of alprazolam tablets

NS Nudelman, CG Cabrera

文献索引：Nudelman, Norma S.; Cabrera, C. Gallardo Journal of Pharmaceutical Sciences, 2002 , vol. 91, # 5 p. 1274 - 1286

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被引用次数: 23

摘要

Abstract Accelerated thermal, hydrolytic, and photochemical degradations of alprazolam were performed under several reaction conditions. The stress studies revealed the photolability of the drug as the most adverse stability factor; the main photodegradation products were isolated and properly characterized as: triazolaminoquinoleine; 5-chloro- [5‵‵-methyl-4H-1, 2, 4-triazol-4-yl] benzophenone, and 1-methyl-6-phenyl-4H-s-triazo-[4 ...