Abstract Accelerated thermal, hydrolytic, and photochemical degradations of alprazolam were performed under several reaction conditions. The stress studies revealed the photolability of the drug as the most adverse stability factor; the main photodegradation products were isolated and properly characterized as: triazolaminoquinoleine; 5-chloro- [5‵‵-methyl-4H-1, 2, 4-triazol-4-yl] benzophenone, and 1-methyl-6-phenyl-4H-s-triazo-[4 ...