A Concise Synthesis of the DNA??Intercalating and Antimalarial Alkaloid Cryptolepine and Its Fluorescence Behaviour in Solvents of Different Polarities

…, J Banerji, D Sarkar, N Chattopadhyay

文献索引：Lai, Tapan Kumar; Chatterjee, Asima; Banerji, Julie; Sarkar, Deboleena; Chattopadhyay, Nitin Helvetica Chimica Acta, 2008 , vol. 91, # 10 p. 1975 - 1983

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被引用次数: 7

摘要

Abstract A microwave-induced rapid and facile synthesis of the DNA-intercalating and antimalarial drug cryptolepine is described. The key step in this synthesis involves the aqueous-phase base-catalyzed condensation of isatin and 1-acetyl-1H-indol-3-yl acetate which has been simplified and expedited by dielectric heating, employing an ordinary domestic microwave oven. The method transforms the synthesis of an important drug ...