Journal of the American Chemical Society

Detection of aminium ion intermediates: N-cyclopropyl versus N-carboxymethyl groups as reporters

RA Totah, RP Hanzlik

文献索引：Totah; Hanzlik Journal of the American Chemical Society, 2001 , vol. 123, # 41 p. 10107 - 10108

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被引用次数: 5

摘要

Oxidative N-dealkylation is the single most common reaction in the biotransformation of alkylamines. This process is catalyzed by a range of enzymes including the flavoproteins, monoamine oxidase and sarcosine oxidase, the quinoproteins diamine oxidase, lysyl oxidase, methylamine dehydrogenase, and plasma amine oxidase, the non-heme iron oxidase ACC oxidase, and the hemethiolate cytochromes P450. N-Dealkylations ...