A Simple Strategy for the Preparation of 6-Substituted 3 H-Benzoxazol-2-ones and 3 H-Benzothiazol-2-ones
RJ DeOrazio, JH Maeng, DD Manning…
文献索引：Deorazio, Russell J.; Maeng, Jun-Ho; Manning, David D.; Sherer, Brian A.; Scott, Ian L.; Nikam, Sham S. Synthetic Communications, 2011 , vol. 41, # 23 p. 3551 - 3555
Abstract The double metallation of 6-bromo-3 H-benzothiazol-2-one and 6-bromo-3 H- benzoxazol-2-one with methyl magnesium bromide and alkyllithium bases is described. Alkylation with a variety of electrophiles occurs at the 6-position of the heterocycles in good yields.
