N-Phosphonocarbonylpyrrolidine derivatives of guanine: a new class of bi-substrate inhibitors of human purine nucleoside phosphorylase

…, N Panova, P Klener, B Maswabi, R Pohl…

文献索引：Rejman, Dominik; Panova, Natalya; Klener, Pavel; Maswabi, Bokang; Pohl, Radek; Rosenberg, Ivan Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1612 - 1621

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被引用次数: 16

摘要

A complete series of pyrrolidine nucleotides,(3 R)-and (3 S)-3-(guanin-9-yl) pyrrolidin-1-N- ylcarbonylphosphonic acids and (3 S, 4 R)-,(3 R, 4 S)-,(3 S, 4 S)-, and (3 R, 4 R)-4-(guanin-9- yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acids, were synthesized and evaluated as potential inhibitors of purine nucleoside phosphorylase (PNP) isolated from peripheral blood mononuclear cells (PBMCs) and cell lines of myeloid and lymphoid origin. Two ...