A complete series of pyrrolidine nucleotides,(3 R)-and (3 S)-3-(guanin-9-yl) pyrrolidin-1-N- ylcarbonylphosphonic acids and (3 S, 4 R)-,(3 R, 4 S)-,(3 S, 4 S)-, and (3 R, 4 R)-4-(guanin-9- yl)-3-hydroxypyrrolidin-1-N-ylcarbonylphosphonic acids, were synthesized and evaluated as potential inhibitors of purine nucleoside phosphorylase (PNP) isolated from peripheral blood mononuclear cells (PBMCs) and cell lines of myeloid and lymphoid origin. Two ...
