Journal of the Chemical Society, Perkin Transactions 2

Regioselectivity and mechanism of transpurination reactions in theguanine nucleosides series

J Boryski

文献索引：Boryski, Jerzy Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 3 p. 649 - 652

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被引用次数: 25

摘要

The transpurination reaction of the fully acetylated derivatives of guanosine and its 7-β-D- ribofuranosyl regioisomer with 2-acetoxyethyl acetoxymethyl ether has been studied using high performance liquid chromatography (HPLC). The regioselectivity of glycosyl exchange observed in the early stages of the reaction suggests that the unsubstituted nitrogen atoms of the imidazole portion (N7 and N9) are, exclusively, sites of direct glycosylation in the ...