Tetrahedron

Nitroolefins in one-flask, tandem. A+ B+ C coupling reactions producing heterocycles

GH Posner, RD Crouch

文献索引：Posner, Gary H.; David Crouch Tetrahedron, 1990 , vol. 46, # 21 p. 7509 - 7530

全文：HTML全文

被引用次数: 30

摘要

Nitroolefins are shown to be effective Michael acceptor B units in sequential, convenient, multi-gram scale A+ B+ C coupling in one reaction vessel to produce nitroalkane intermediates that are converted into oxygen and nitrogen heterocycles. The sequence is initiated by enolate nucleophiles (A) and is terminated by aldehydes or acrylate electrophiles (C). The utility of this protocol for rapid assembly of complex structures from ...