CuCN catalyzed one pot synthesis of γ-keto diesters: domino double Michael addition followed by Nef reaction

S Farooq, PL Sangwan, RR Aleti, PK Chinthakindi…

文献索引：Farooq, Saleem; Sangwan, Payare L.; Aleti, Rajeshwar R.; Chinthakindi, Praveen K.; Qurishi, Mushtaq A.; Koul, Surrinder Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3305 - 3309

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被引用次数: 6

摘要

An efficient one pot synthesis of γ-keto diesters through double Michael addition coupled with Nef reaction in the presence of CuCN catalyst and Cs2CO3 base is described. The reaction proceeds rapidly in DCM to give the products in good yields. A plausible mechanism is proposed.