Chemistry Letters

A convenient method for the synthesis of 4-chloro-3-alkenoic acid. A new useful synthetic block for 4-oxoalkanoic and 4-oxo-2-alkenoic acids

M Kawashima, T Fujisawa

文献索引：Kawashima, Masatoshi; Fujisawa, Tamotsu Chemistry Letters, 1984 , p. 1851 - 1854

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被引用次数: 3

摘要

Easily available material, β-(1-chlorovinyl)-β-propiolactone reacted with organocopper reagents to afford 4-chloro-3-alkenoic acids in high yields. The acids were easily transformed into two kinds of useful carboxylic acids such as 4-oxoalkanoic and 4-oxo-(E)-2- alkenoic acids leading to various natural products.